Destrehan is a census-designated place (CDP) in St. Charles Parish.

St. Charles Parish Public School System operates Destrehan’s public schools. The public schools in the city are New Sarpy Elementary (PK-3), Ethel Schoeffner Elementary (4-6), Harry Hurst Middle (7-8), and Destrehan High School (8-12). Destrehan is also home to St. Charles Borromeo School (PK-8) as well as many private preschools.